FSH Directly Regulates Bone Mass
نویسندگان
چکیده
منابع مشابه
FSH Directly Regulates Bone Mass
Postmenopausal osteoporosis, a global public health problem, has for decades been attributed solely to declining estrogen levels. Although FSH levels rise sharply in parallel, a direct effect of FSH on the skeleton has never been explored. We show that FSH is required for hypogonadal bone loss. Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism. Bone ma...
متن کاملSex Steroids, Not FSH, Influence Bone Mass
Hypogonadism, whether caused by the failure of gonadal development or function, frequently results in bone loss. In a research article in the April 21, 2006 issue of Cell, Sun et al. investigated the role of follicle-stimulating hormone (FSH) in the bone loss that is characteristic of hypogonadal mice. They report that female mice lacking either FSHβ or its receptor (FSHR) are resistant to bone...
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In our study (Sun et al., 2006), we conclude that FSH has a direct role in causing bone loss in hypogonadal mice. Our study does not, however, imply that estrogen and testosterone are not critical regulators of bone mass. To the contrary, we assert that sex steroids regulate bone formation and bone resorption, whereas FSH directly stimulates bone resorption. Problems in interpretation can arise...
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Recent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. Here, we discuss the topical evidence about the dysfunction of the pituitary-bone axis that leads to osteoporotic bone loss. We will explore the context of FSH and TSH hormones arguing their direct or indirect ro...
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ژورنال
عنوان ژورنال: Cell
سال: 2006
ISSN: 0092-8674
DOI: 10.1016/j.cell.2006.01.051